Ribosome Biogenesis
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The ribosome is one of the most complex machines in the cell. We work on how eukaryotic cells assemble, transport, and test ribosomes for function. We primarily use yeast as a model system because the molecular techniques, genetic reagents and bioinformatics are more robust for yeast than for any other system.
Featured Articles
P. Sutjita, J. Recchia-Rife, S. Musalgaonkar, L. Huang B. Xhemalce and A.W. Johnson.
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A single 2'-O-methylation of ribosomal RNA gates assembly of a functional ribosome
Yelland JN, Bravo JPK, Black JJ, Taylor DW, Johnson AW. Nat Struct Mol Biol. 2023 Jan.
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Release of the ribosome biogenesis factor Bud23 from small subunit precursors in yeast
Black JJ, Johnson AW. RNA. 2022 Mar.
Black JJ & Johnson AW. Current Genetics. 2021 Apr.
Bud23 promotes the final disassembly of the small subunit Processome in Saccharomyces cerevisiae
Black JJ, Sardana R, Elmir EW, Johnson AW. PLoS Genetics. 2020 Dec.
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The L1 stalk is required for efficient export of nascent large ribosomal subunits in yeast
Musalgaonkar S, Black JJ, Johnson AW. RNA 2019 Nov.
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Tsr4 is a cytoplasmic chaperone for the ribosomal protein Rps2 in Saccharomyces cerevisiae
Black JJ, Musalgaonkar S, Johnson AW. Mol. Cell. Biol. 2019 Jun.
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Tightly-orchestrated rearrangements govern catalytic center assembly of the ribosome
Zhou, Y, Musalgaonkar, S, Johnson, AW and Taylor, DW. Nat. Commun. 2019 Feb.
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Happenings
01/2024 – Ruta Chitale officially joins the lab
08/2023 – Jamie joins Arvind (Rasi) Subramanian's lab at the Fred Hutchinson Cancer Center, Seattle.
07/2022 – Sharmishtha takes a job at SalioGen Therapeutics.
07/2022 – Dr. Trey Sutjita successfully defends her thesis!
01/2022 – Josh Black begins a postdoc with Rachel Green at John's Hopkins!
11/2021 – Richa Sardana opens her lab at Cornell in the Department of Molecular Medicine!
09/2021 – Sabine Mohr joins our group as a Research Associate!
07/2021 – Congratulations to Dr. Joshua Black for successfully defending your thesis!
01/2021 – We welcome Ran Lin as the newest member of our lab as a post-doctoral researcher!