The ribosome is one of the most complex machines in the cell. We work on how eukaryotic cells assemble, transport, and test ribosomes for function. We primarily use yeast as a model system because the molecular techniques, genetic reagents and bioinformatics are more robust for yeast than for any other system.
Tsr4 is a cytoplasmic chaperone for the ribosomal protein Rps2 in Saccharomyces cerevisiae. Black JJ, Musalgaonkar S, Johnson AW. Mol. Cell. Biol. 2019 June 10. doi: 10.1128/MCB.00094-19.
Tightly-orchestrated rearrangements govern catalytic center assembly of the ribosome. Zhou, Y, Musalgaonkar, S, Johnson, AW and Taylor, DW. Nat. Commun. 2019 Feb 27;10(1):958. doi: 10.1038/s41467-019-08880-0.
Utp14 interaction with the small subunit processome. Black JJ, Wang Z, Goering LM, Johnson AW. RNA. 2018 24:1214-1228. doi: 10.1261/rna.066373.118.
The T-cell leukemia related rpl10-R98S mutant traps the 60S export adapter Nmd3 in the ribosomal P site in yeast. Patchett S, Musalgaonkar S, Malyutin AG, Johnson AW. PLoS Genet. 2017 Jul 17;13(7):e1006894.
05/2019 Congratulations Lisa Huang for getting into MD Anderson's graduate school!
05/2019 Congratulations Hana Shin for getting into MD Anderson's graduate school!
05/2019 Congratulations Daniel Loftus for joining Amanda Whipple's lab at Harvard University!
05/2019 Congratulations Andrew Bazley for getting into graduate school at New York University!
03/2019 Congratulations Jamie Yelland on passing your PhD Candidacy Qualification Exam!